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Sports Med 2007; 37 (6): 519-532
R
EVIEW
A
RTICLE
0112-1642/07/0006-0519/$44.95/0
©
2007 Adis Data Information BV. All rights reserved.
The Role of Nutritional Supplements
in the Prevention and Treatment of
Resistance Exercise-Induced Skeletal
Muscle Injury
Richard J. Bloomer
Department of Health and Sport Sciences, The University of Memphis, Memphis,
Tennessee, USA
Contents
Abstract . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 519
1. Skeletal Muscle Injury . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 521
2. Nutritional Supplements to Reduce Skeletal Muscle Injury . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 522
2.1 Antioxidants . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 522
2.2
-Hydroxy-
-Methylbutyrate . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 528
2.3 Miscellaneous Supplements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 529
3. Conclusion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 530
The topic of exercise-induced skeletal muscle injury has received considerable
Abstract
attention in recent years. Likewise, strategies to minimise the injury resulting
from heavy resistance exercise have been studied. Over the past 15 years, several
investigations have been performed focused on the role of nutritional supplements
to attenuate signs and symptoms of muscle injury. Of these, some have reported
favourable results, while many others have reported no benefit of the selected
nutrient. Despite these mixed findings, recommendations for the use of nutritional
supplements for the purposes of attenuating muscle injury are rampant within the
popular fitness media and athletic world, largely without scientific support. Those
nutrients include the antioxidant vitamin C (ascorbic acid) and vitamin E (tocoph-
erol), N-acetyl-cysteine, flavonoids, L-carnitine, astaxanthin,
-hydroxy-
-
methylbutyrate, creatine monohydrate, essential fatty acids, branched-chain
amino acids, bromelain, proteins and carbohydrates. A discussion of all published
peer-reviewed articles in reference to these nutrients and their impact on resis-
tance exercise-induced skeletal muscle injury is presented, in addition to a brief
view into the potential mechanism of action for each nutrient.
Based on the current state of knowledge, the following conclusions can be
made with regard to nutritional supplements and their role in attenuating signs and
symptoms of skeletal muscle injury occurring as a consequence of heavy resis-
tance exercise: (i) there appears to be a potential role for certain supplements
(vitamin C, vitamin E, flavonoids, and L-carnitine); (ii) these supplements cannot


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